Helpful Programs Related to the Poolfit Project

Estimating haplotype frequencies from genotype data at multiple loci
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Constraint equations that integrate mass measurements with tracer data in compartmental models

Power analysis for common clinical research designs

Some Relevant Publications

Rajasekhar Ramakrishnan 2006. Studying apolipoprotein turnover with stable isotope tracers: correct analysis is by modeling enrichments. Journal of Lipid Research 47(12):2738-2753

Roshni R. Singaraja, Bjorn Stahmer, May Brundert, Martin Merkel, Joerg Heeren, Nagat Bissada, Martin Kang, Jenelle M. Timmins, Rajasekhar Ramakrishnan, John S. Parks, Michael R. Hayden, and Franz Rinninger 2006. Hepatic ATP-Binding Cassette Transporter A1 Is a Key Molecule in High-Density Lipoprotein Cholesteryl Ester Metabolism in Mice Arterioscler. Thromb. Vasc. Biol. 26:1821-827.

Rubin J, Kim HJ, Pearson TA, Holleran S, Ramakrishnan R, Berglund L 2006. Apo(a) size and PNR explain African American-Caucasian differences in allele-specific apo[a] levels for small but not large apo[a]. J Lipid Res. 47(5):982-9.

Myerson M, Ngai C, Jones J, Holleran S, Ramakrishnan R, Berglund L, Ginsberg HN 2005. Treatment with high-dose simvastatin reduces secretion of apolipoprotein B-lipoproteins in patients with diabetic dyslipidemia. J Lipid Res. 46(12):2735-44.

Seo T, Qi K, Chang C, Liu Y, Worgall TS, Ramakrishnan R, Deckelbaum RJ 2005. Saturated fat-rich diet enhances selective uptake of LDL cholesteryl esters in the arterial wall. J Clin Invest. 115(8):2214-22.

Nagashima, K., C. Lopez, D. Donovan, C. Ngai, N. Fontanez, A. Bensadoun, J. Fruchart-Najib, S. Holleran, J. S. Cohn, R. Ramakrishnan, and H.N.Ginsberg 2005. Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus. J. Clin. Invest. 115: 1323?1332.

Richard S Bruno, Rajasekhar Ramakrishnan, Thomas J Montine, Tammy M Bray, and Maret G Traber 2005. {alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status. Am. J. Clinical Nutrition 81: 95-103.

Brundert M, Ewert A, Heeren J, Behrendt B, Ramakrishnan R, Greten H, Merkel M, Rinninger F 2005. Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice. Arterioscler Thromb Vasc Biol. 25(1):143-8.

Leonard SW, Bruno RS, Ramakrishnan R, Bray T, Traber MG 2004. Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC. Ann N Y Acad Sci. 1031:357-60.

Berglund L, Ramakrishnan R 2004. Lipoprotein(a): an elusive cardiovascular risk factor. Arterioscler Thromb Vasc Biol. 24(12):2219-26.